Targeting insulin-producing beta cells for regenerative therapy
نویسندگان
چکیده
منابع مشابه
Targeting development of incretin-producing cells increases insulin secretion.
Glucagon-like peptide-1-based (GLP-1-based) therapies improve glycemic control in patients with type 2 diabetes. While these agents augment insulin secretion, they do not mimic the physiological meal-related rise and fall of GLP-1 concentrations. Here, we tested the hypothesis that increasing the number of intestinal L cells, which produce GLP-1, is an alternative strategy to augment insulin re...
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Diabetes, a large and growing worldwide health concern, affects the functional mass of the pancreatic beta cell, which in turn affects the glucose regulation of the body. Successful transplantation of cadaveric islets and pancreata for patients with uncontrolled type 1 diabetes has provided proof-of-concept for the development of commercial cell therapy approaches to treat diabetes. Three broad...
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The integrity and normal function of the corneal epithelium are essential for maintaining the cornea's transparency and vision. The existence of a cell population with progenitor characteristics in the limbus maintains a dynamic of constant epithelial repair and renewal. Currently, cell-based therapies for bio-replacement, such as cultured limbal epithelial transplantation and cultured oral muc...
متن کاملNew sources for insulin-producing cells.
Cellular replacement offers the potential of a `cure` for type 1 diabetes mellitus. Shortage of suitable donors limits widespread implementation of this approach. Recent research has been focused on potential new sources of beta-cells including embryonic and adult stem cells, and other organs cells. The contribution of beta-cell replication to new islet formation, in addition to the potential f...
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Background & Objective: Diabetes is a major chronic metabolic disease in the world. Islet transplantation is a way to treat diabetes. Unfortunately, this method is restricted due to graft rejection and lack of donor islets. Mesenchymal Stem Cells (MSCS) have the ability to differentiate into Insulin-Producing Cells (IPCs). In this study, Human Umbilical Mesenchymal Stem Cells (HUMSCS) were in...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2016
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-016-3949-9